DNA-Encoded Chemical Libraries (DELs) for drug discovery

DNA-Encoded Chemical Libraries (DELs) feature small molecules individually tagged with a DNA barcode, which allows for the identification of target-binding ligands after PCR amplification and DNA sequencing.

DEL technology which was pioneered ETH Zurich has become an indispensable tool for small molecule drug discovery. The standard implementation, as integrated in most of the larger pharmaceutical companies, proves to be efficacious for small-molecule discovery.

In this presentation, I will summarize the development of DEL technology and discuss novel., promiosing aspects of DEL technology such as enabling a newly addressable chemical space through small macrocyclic DELs.

Prof. Jörg Scheuermann
ETH Zurich - Chemistry and Applied Biosciences Institute of Pharmaceutical Sciences